It's called "Borderlands" because it metaphorises consumerism in the american society. The "border" represents the limits of a capitalism system within the global paradigm, while the "lands" are the countries involved in this issue. It's "2" because there is a metaphorical inclusing of the spectator, "us too", or "us 2", as to make us feel concerned about the state of the economy in this country.
Handsome Jack, for instance, is a clear personification of the ever-nagging Dow Jones indices, which can be reflected as the pulse of the economy. Tiny Tina would be petrol exploitation companies, which are usually fond of high explosives and slang-talking.
I sincerely apologize if this message offended you in any way. Let it known that I value your opinion and that I respect you as a person.